Tuesday, 31 May 2011
Melanoma – Prognostic Factors – Quick Overview
Listed below are the most important prognostic factors with regard to cutaneous melanoma.
AGE – the older the patient, the poorer the prognosis.
SEX – generally females have a better prognosis than males.
BODY SITE – melanomas on the extremities (eg. legs and arms) have a better prognosis than those on the neck, trunk and face.
INVOLVEMENT OF LYMPH NODES – presence of tumour lymph node involvement has a poorer prognosis. Generally the more nodes involved the poorer the prognosis.
TUMOUR THICKNESS – the thicker the melanoma the poorer the prognosis.
ULCERATION – the presence of ulceration indicates a poorer prognosis.
MITOTIC RATE – the higher the mitotic rate the poorer the prognosis.
REGRESSION – presence of regression in thin melanomas indicates a poorer prognosis.
There are a few other prognostic factors such as Clarks level, tumour-infiltrating lymphocytes, BRAF mutations and LDH (lactate dehydrogenase) serum level.
Many thanks for reading and please leave any comments you wish.
Keep an eye out for my website coming soon www.skinpathonline.com
Follow me on twitter as well (@skinpathology)
My email is email@example.com for any questions or queries.